When she swallows the first pill and hears What’s up, Freckles?, she understands how Jack felt. Too late, as always.

That line gave me chills.

Wow, this is a real great idea. And they are all taking the same drug^^

The bitter irony of it, is that he started taking it in order not to see his father anymore; he always shows up as soon as he swallows one down.

Aww, poor Jack. Very ironic.